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Frankfurt Cathedral is not a cathedral, but the main Catholic church, dedicated to St. Bartholomew. The Gothic building was constructed in the 14th and 15th centuries on the foundation of an earlier church from the Merovingian time. From 1356 onwards, kings of the Holy Roman Empire were elected in this church, and from 1562 to 1792, Roman-German emperors were crowned there. It is one of Germany's largest with over 90 companies from the pharmaceutical, the chemical and the biotechnology industry, including Celanese, Clariant, BASF, Merck KGaA and Siemens. At the beginning of the 1980s Hoechst AG was the largest pharmaceutical corporation and Industriepark Höchst was known as "the pharmacy of the world". Hoechst AG merged with Rhône-Poulenc to become Aventis in 1999 and in 2004 Aventis merged with Sanofi-Synthélabo to become Sanofi-Aventis.
Frankfurt Central Station (Frankfurt Hauptbahnhof, often abbreviated as Frankfurt Hbf or F-Hbf) is the largest railway station in Germany by railway traffic. By daily passenger volume, it ranks second together with Munich Central Station after Hamburg Central Station . It is located between the Gallus, the Gutleutviertel and the Bahnhofsviertel district, not far away from the trade fair and the financial district.
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Major companies in Eschborn include Ernst & Young, Vodafone Germany, Randstad Holding and VR Leasing. Frankfurt is home to the German headquarters of Nestlé, the world's largest food company, located in Niederrad. Other important food companies are Ferrero SpA and Radeberger Gruppe KG, the largest private brewery group in Germany.

The Lufthansa Aviation Center is the main operation base of Lufthansa at Frankfurt Airport. The airport serves as Lufthansa's primary hub with 157 worldwide destinations (compared to 110 destinations at Munich Airport, Lufthansa's second-largest hub). Lufthansa Cargo is based in Frankfurt and operates its largest cargo center at Frankfurt Airport. Deutsche Börse's headquarters are formally registered in Frankfurt, but it moved most of its employees to a high-rise called "The Cube" in Eschborn in 2010, primarily due to significantly lower local corporate taxes. On 1 February 2012 European Commission blocked the proposed merger of Deutsche Börse and NYSE Euronext.
Neighboring districts and cities
Due to its location at the northern tip of the Upper Rhine Valley in the Southwest of Germany, Frankfurt is one of the warmest and driest bigger German cities together with cities like Darmstadt, Mannheim, Karlsruhe and Freiburg im Breisgau. Summers in Frankfurt can get very warm, when compared to the rest of the country. Between the years 1981 and 2010 there have been 52 days in Frankfurt with a maximum temperature over 25 °C and 13 days with a maximum over 30 °C on average per year. Frankfurt at the heart of the densely populated Frankfurt Rhine-Main Metropolitan Region with a population of 5.5 million. Other important cities in the region are Wiesbaden , Mainz (capital of Rhineland-Palatinate), Darmstadt, Offenbach am Main, Hanau, Aschaffenburg, Bad Homburg vor der Höhe, Rüsselsheim, Wetzlar and Marburg.

The oldest and best-known university is the Johann Wolfgang Goethe University, with locations in Bockenheim, Westend, and Riedberg, and the university hospital in Niederrad. Goethe Business School is part of the university's House of Finance at Campus Westend. The Business School's Full-Time MBA program has over 70% international students. As a profoundly international city, Frankfurt hosts 92 diplomatic missions (consulates and consulates-general). Worldwide, only New York City and Hamburg are non-capital cities with more foreign representation. The Consulate General of the United States in Eckenheim is the largest American consulate in the world.
Sights in the Frankfurt Rhein-Main-Area
The Bankenviertel , Frankfurt's financial district, is also not an administrative city district . Frankfurt has many downtown high-rise buildings that form its renowned Frankfurt skyline. In fact, it is one of the few cities in the European Union to have such a skyline, which is why Germans sometimes refer to Frankfurt as Mainhattan, combining the local river Main and "Manhattan". Before World War II the city was noted for its unique old town, the largest timber-framed old town in Europe.
Other major companies are Hewlett-Packard, Bridgestone, Deutsche Leasing and Basler Versicherungen. This is partly attributed to the financial sector, but also to its cosmopolitan nature, with expatriates and immigrants representing one-fourth of its population. For this reason, Frankfurt's property market often operates differently than the rest of the country where the prices are generally flatter.
In 2011, Ticona now part of Celanese, an international manufacturer of engineering polymers, moved to Industriepark Höchst. DWS Investments is the largest investment trust company in Germany and manages €288 billion fund assets. It is one of the 10 largest investment trust companies in the world. The largest company at Frankfurt Airport is Lufthansa, Germany's flag carrier and Europe's largest airline.

During the Nazi era, the synagogues of the city were destroyed and the vast majority of the Jewish population fled or was killed. Frankfurt lost its independence after the Austro-Prussian War in 1866 when Prussia annexed several smaller states, among them the Free City of Frankfurt. The Prussian administration incorporated Frankfurt into its province of Hesse-Nassau. The Prussian occupation and annexation were perceived as a great injustice in Frankfurt, which retained its distinct western European, urban and cosmopolitan character. The formerly independent towns of Bornheim and Bockenheim were incorporated in 1890. ("prince of Venice", a newly established primogeniture in Italy), Grand Duke of Frankfurt after Dalberg's death .
It is located between the financial district and downtown, running from Goetheplatz to Opernplatz. Großmarkthalle, built 1926–1928 as a part of the New Frankfurt-project, the former wholesale market hall was repaired after the second world war and integrated into the new seat of the European Central Bank between 2010 and 2014. Frauenfriedenskirche and Holy Cross Church), both consecrated in 1929, are examples of early modernist church buildings during the time of the New Frankfurt.

"Wäldches" is a regional dialect of the German word "Wäldchen", meaning "small forest". The Squaire , also known as Airrail Center Frankfurt, is a 660 m (2,165.35 ft) long and 45 m (147.64 ft) tall office building located at Frankfurt Airport. It was built from 2006 to 2011 on top of an existing railway station and has a connecting bridge to Terminal 1 for pedestrians.
Messeturm, built on the trade fair site, reached a height of 256.5 meters and became the tallest building in Europe by 1991. Other tall buildings from this decade are Westendstrasse 1 (208 meters ), Main Tower (200 meters ) and Trianon (186 meters ). Frankfurt Central Station , which opened in 1888, was built as the central train station for Frankfurt to replace three smaller downtown train stations and to boost the needed capacity for travellers. It was constructed as a terminus station and was the largest train station in Europe by floor area until 1915 when Leipzig Central Station was opened. Its three main halls were constructed in a neorenaissance-style, while the later enlargement with two outer halls in 1924 was constructed in neoclassic-style. The Saalhof is the oldest conserved building in the Altstadt district and dates to the 12th century.

The city has many notable various green areas and parks, including the central Wallanlagen, the City Forest, two major botanical gardens and the Frankfurt Zoo. In sports, the city is known as the home of the top-tier soccer club Eintracht Frankfurt, the Löwen Frankfurt ice hockey team, the basketball club Frankfurt Skyliners, the Frankfurt Marathon and the venue of Ironman Germany. It was also one of the host cities of the 1974 and 2006 FIFA World Cups. Nine S-Bahn lines connect Frankfurt with the densely populated Rhine Main Region.
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Frankfurt Airport is one of the busiest airports in the world and is also the single largest place of work in Germany with over 500 companies which employ 71,500 people . DekaBank – DekaBank is the central asset manager of the Sparkassen in Germany. The headquarters of DekaBank are located at the Trianon skyscraper at Mainzer Landstraße. It covers the area of Frankfurt Airport that had belonged to Sachsenhausen and the neighboring city of Mörfelden-Walldorf. During the 1970s, the city created one of Europe's most efficient underground transportation systems. That system includes a suburban rail system (S-Bahn) linking outlying communities with the city center, and a deep underground light rail system with smaller coaches (U-Bahn) also capable of travelling above ground on rails.
PricewaterhouseCoopers German headquarters are located at Tower 185. Deloitte Touche Tohmatsu are present, while Ernst & Young is located in Eschborn. Three of the four largest international accountancy and professional services firms are present. In 2009, Commerzbank merged with competitor Dresdner Bank, then the third-largest German bank. Due to the merger and the higher credit risks, Commerzbank was 25% nationalized during the Great Recession. Its headquarters are at Commerzbank Tower , the second-tallest building in the EU, at Kaiserplatz.